•COLLAGEN METABOLISM IN • •. RHEUMATOlD ARTHRITIS AND OSTEOARTHRITJS
NAGLM YOUSSEF MOHAMED ASSAF;
Abstract
Collagen is the major macromo!scule component of the connective tissue, and the differences in connective tissues are in part attributable to the differences in their contents of eollagen macromolecules (Prockop' and Kivirikko, 1984).
In chronic joint diseases there is inflammatory changes in the synovial membrane (synovitis), with alteration in the extracellular matrix metabolism of the articulator cartilage, adjacent bone and surrounding connective tissues.
The degree of synovial inflammation varies, it is much greater in some conditions like RA than in others, and more over the nature of this .syriovial response may vary with the different degrees of s:Ynovial proliferation. Synovial inflammation and proliferation is usually associated with an enhanced synthesis and deposition of collagen I and III in the synovial tissue (Hakala et aL, 1995). Also the synovial cells especially the fibroblast-like synoviocytes (FLS)- under the effect of cytokines especially ILl and 1NFa- secrete prostaglandins and proteolytic enzymes including collagenase and stromelysin which degrade collagen and proteoglycans (Marita et aL, 1997).
When proliferation and/or degradation of collagen takes place in chronic joint diseases, there is increase in the concentration of collagen derived substances, like ICTP and PIIINP (Fleischmajer et aL, 1981).
In chronic joint diseases there is inflammatory changes in the synovial membrane (synovitis), with alteration in the extracellular matrix metabolism of the articulator cartilage, adjacent bone and surrounding connective tissues.
The degree of synovial inflammation varies, it is much greater in some conditions like RA than in others, and more over the nature of this .syriovial response may vary with the different degrees of s:Ynovial proliferation. Synovial inflammation and proliferation is usually associated with an enhanced synthesis and deposition of collagen I and III in the synovial tissue (Hakala et aL, 1995). Also the synovial cells especially the fibroblast-like synoviocytes (FLS)- under the effect of cytokines especially ILl and 1NFa- secrete prostaglandins and proteolytic enzymes including collagenase and stromelysin which degrade collagen and proteoglycans (Marita et aL, 1997).
When proliferation and/or degradation of collagen takes place in chronic joint diseases, there is increase in the concentration of collagen derived substances, like ICTP and PIIINP (Fleischmajer et aL, 1981).
Other data
| Title | •COLLAGEN METABOLISM IN • •. RHEUMATOlD ARTHRITIS AND OSTEOARTHRITJS | Other Titles | عملية ايض الكولاجين فى الرثيان المفصلى والالتهاب العظمى المفصلى | Authors | NAGLM YOUSSEF MOHAMED ASSAF | Issue Date | 2000 |
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