Effect of Magnesium Sulfate on Doppler Parameters of Fetal Umbilical and Middle Cerebral Arteries in Women with Severe Preeclampsia

Abstract

Summary H ypertensive pregnancy disorders complicate 10% of all pregnancies and cover a spectrum of conditions, namely preeclampsia, eclampsia, and chronic and gestational hypertension. Pre-eclampsia, a human-pregnancy-specific disease defined as new hypertension presenting after 20 weeks with significant proteinuria which in turn is defined as urinary protein: creatinine ratio is greater than 30 mg/mmol or a validated 24-hour urine collection result shows greater than 300 mg protein. In a study was performed in 2013, the American College of Obstetricians and Gynecologists removed proteinuria as an essential criterion for diagnosis of preeclampsia with severe features. In developing countries, a woman is seven times more likely to develop preeclampsia than a woman in a developed country. From 10-25% of these cases will result in maternal death. The principal therapeutic indication of MgSO4has been its use in the prevention of eclamptic seizures in patients with severe preeclampsia as well as fetal neuroprotection compared to other anticonulsants as phenytoin.