Comparative Study between Different Modalities in Management of Advanced Prostate Cancer
Mina Ibrahim Aziz;
Abstract
P
C is the most reported male cancer as well as the second leading cause of cancer-related deaths in Western men, excluding non-melanoma skin diseases. Ever since 1941, when it was discovered that lowering testosterone levels via orchiectomy or estrogen injections improved symptoms in patients with metastatic, exogenous hormone naïve disease, ADT(ADT) became the mainstay treatment for locally advanced PC (clinical tumor stages T3–T4, PSA > 20 ng/mL). However, despite reducing testosterone production to castrate levels (≤50 ng/ dL), many patients will relapse and develop castration resistant disease within 2–3 years post treatment, that is often more aggressive, currently incurable and has a poor prognosis with only 16–18 months of survival.
C is the most reported male cancer as well as the second leading cause of cancer-related deaths in Western men, excluding non-melanoma skin diseases. Ever since 1941, when it was discovered that lowering testosterone levels via orchiectomy or estrogen injections improved symptoms in patients with metastatic, exogenous hormone naïve disease, ADT(ADT) became the mainstay treatment for locally advanced PC (clinical tumor stages T3–T4, PSA > 20 ng/mL). However, despite reducing testosterone production to castrate levels (≤50 ng/ dL), many patients will relapse and develop castration resistant disease within 2–3 years post treatment, that is often more aggressive, currently incurable and has a poor prognosis with only 16–18 months of survival.
Other data
| Title | Comparative Study between Different Modalities in Management of Advanced Prostate Cancer | Other Titles | دراسة مقارنة بين طرق العلاج المختلفة للأورام المتقدمة للبروستاتا | Authors | Mina Ibrahim Aziz | Issue Date | 2017 |
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