Th 17 and T reg cells in type 2 diabetic nephropathy

Abstract

Type 2 diabetes mellitus is the most common human endocrine disease in which diabetic nephropathy take place nearby 25% approximately of patients. Type 2 diabetes mellitus and type 2 diabetic nephropathy considered to be an inflammatory process in which immune cells are involved in its development and progression apart from traditional metabolic and hemodynamic risk factors. Our study included 3 groups; group A: 30 type 2 diabetic nephropathy patients (on basis of proteinuria and reduced GFR), group B: 30 type 2 diabetic patients (according to American Diabetes Association, 2013 criteria) and group C: 20 healthy controls of the same age and sex. Our study, aimed to determine the balance between T helper 17 and regulatory T cells in type 2 diabetic patients having diabetic nephropathy in relation to type 2 diabetic patients without renal involvement andhealthy individuals. The results revealed that there was higher mean Th17 and Th17/Treg cells ratio among type 2 diabetic nephropathy patients compared to other groups. And, there was lower mean Tregcells among type 2 diabetic nephropathy patients compared to other groups with very high statistically significant differences. Also, there was higher mean Th17 and Th17/Treg cells ratio among type 2 diabetic patients compared to healthy individuals with very high statistically significant differences. While, type 2 diabetic patients and healthy individuals were comparable as regards meanTreg cells with no statistical significant difference.