Diagnostic &Prognostic value of Platelet Activated Derived Micro-particles in Neonatal Sepsis

Abstract

The present study was designed to evaluate the role of PlateletActivated Microparticles as a diagnostic and prognostic tool in neonatal sepsis. The study was conducted on 25 neonates were diagnosed to have neonatal sepsis {12 males (48%) and 13 females (52%)}, mean gestational age(35.6±2.4 wks), mean birth weight(2.48  0.65kg),with median serum PAMP level before treatment of neonatal sepsis( 25/µl). A healthy neonates{10 males (48%) and 15 females (52%)}with mean gestational age (35.56±2.7weeks)and mean body weight (2.5±0.7 kg) with median serum PAMP (5/µl). All patients in this study were subjected to adequate history taking, full clinical examination, CBC, CRP with titer, blood culture, serum Lactate and serum PAMP at time of diagnosis and 4 days after treatment of sepsis. In our study, there was significant increase in PAMP level in sepsis group, and also it wassignificantly elevated before antimicrobial treatment than after treatment. As the median serum PAMP level in sepsis group was declined from (25/µl) to (10/µl), four days after treatment. There was positive correlation in PAMP level in sepsis group with Tollner and Rodwell sepsis scores initially and at day 4. In this study, there were no significant correlation in PAMP level and demographic data, risk factors, and clinical presentation. There was no significant correlation in PAMP level and laboratory findings. There was significant increase in PAMP level and mortality rate in sepsis group. Our study, revealed the best cutoff value of PAMP level to detect sepsis was (> 12 /µl),with 100% sensitivity & 96% specificity, and PAMP level was reliable to detect sepsis with P (<0.01). This study also showed the prognostic value of PAMP level with 88% sensitivity and 80% specificity.