"Possible Pharmacological Effects of Co - administration of Rosiglitazone and Alpha lipoic acid in Experimentally Induced Diabetes in Rats"
Mohamed Mahmoud M. A min;
Abstract
The present study has been carried out to investigate the possible pharmacological effects that result from the treatment by rosiglitazone a-lipoic acid and their combination in STZ-induced diabetic rats.
The parameters that have been investigated are blood glucose leveL body weight, plasma AST & ALT activities, liver glutathione content. liver IFN -y content and liver histopathology to show possible anti-diabetic, anti-oxidant and anti-inflammatory effects.
Blood glucose level and body weight were determined fuur times during the two weeks oftreatrrent. while other parameters were determined at the end of treatment.
Diabetes was experimentally induced by STZ (60 mg!kg, i.p.). Twenty four hours after injection, diabetic rats were treated with rosiglitazone, a-lipoic acid or their combination for 14 days to study the anti-diabetic, anti-oxidant and anti- inflammatory effects at the end of treatment.
The main results oft he cwTent study will he summarized as follows:
A single i.p. injection of STZ (60 mg!kg) showed a marked increase in blood glucose level, plasma ALT & AST level and liver IFN-y content, while showed a marked decrease in body weight and liver glutathione content of diabetic rats and Kupffer cells activation, vacuolation of Centro lobular hepatocytes, necrosis of sporadic hepatocytcs associated with focal hepatic hemorrhage, cholengitis and pericholengitis.
The parameters that have been investigated are blood glucose leveL body weight, plasma AST & ALT activities, liver glutathione content. liver IFN -y content and liver histopathology to show possible anti-diabetic, anti-oxidant and anti-inflammatory effects.
Blood glucose level and body weight were determined fuur times during the two weeks oftreatrrent. while other parameters were determined at the end of treatment.
Diabetes was experimentally induced by STZ (60 mg!kg, i.p.). Twenty four hours after injection, diabetic rats were treated with rosiglitazone, a-lipoic acid or their combination for 14 days to study the anti-diabetic, anti-oxidant and anti- inflammatory effects at the end of treatment.
The main results oft he cwTent study will he summarized as follows:
A single i.p. injection of STZ (60 mg!kg) showed a marked increase in blood glucose level, plasma ALT & AST level and liver IFN-y content, while showed a marked decrease in body weight and liver glutathione content of diabetic rats and Kupffer cells activation, vacuolation of Centro lobular hepatocytes, necrosis of sporadic hepatocytcs associated with focal hepatic hemorrhage, cholengitis and pericholengitis.
Other data
| Title | "Possible Pharmacological Effects of Co - administration of Rosiglitazone and Alpha lipoic acid in Experimentally Induced Diabetes in Rats" | Other Titles | التأثيرات الفارماكولوجية المحتملة للتناول المتزامن لكلا ً من روزيجلبتازون وحمض الفاليبويك في الجرذان المحدث فيها مرض السكر تجريبيا ً | Authors | Mohamed Mahmoud M. A min | Issue Date | 2010 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.