A Pharmacological study of the effect(s) of Garlic and/or Ginseng on LPS induced Cardiotoxicity in Rats
Eman Abd Al-Hameid Hussein Mahmmoud;
Abstract
The present study was done to investigate the possible protective effect of ginseng extract and fresh garlic, alone or in combination against cardiotoxicity induced by lipopolysaccharide (LPS) in male rats.
Ginseng was given in a dose of I 00 mg/kg for 7 days normal rats or to
others before injection of LPS. Similarly garlic was given to normal rats in a dose of 500 mg/kg to rats for 7 days and for other rats before injection ofLPS.
Lipopolysaccharide was injected as single dose of l mg/kg intraperitonealy as a model of cardiotoxicity in rats.
Cardiotoxicity was assessed through the following parameters:
o ECG interpretation
o Blood Picture
o prothrombin time
o Serum tumor necrosis factor-alpha (TNF-a).
o Heart malondialdehyde (MDA).
o Heart lactate dehydrogenase (LDH).
o Plasma creatine kinase (CK).
o Heart reduced glutathione (GSH).
o Heart glutathione peroxidase (GPX).
o Heart superoxide dimutase (SOD).
o Histopathological examination of heart.
Ginseng was given in a dose of I 00 mg/kg for 7 days normal rats or to
others before injection of LPS. Similarly garlic was given to normal rats in a dose of 500 mg/kg to rats for 7 days and for other rats before injection ofLPS.
Lipopolysaccharide was injected as single dose of l mg/kg intraperitonealy as a model of cardiotoxicity in rats.
Cardiotoxicity was assessed through the following parameters:
o ECG interpretation
o Blood Picture
o prothrombin time
o Serum tumor necrosis factor-alpha (TNF-a).
o Heart malondialdehyde (MDA).
o Heart lactate dehydrogenase (LDH).
o Plasma creatine kinase (CK).
o Heart reduced glutathione (GSH).
o Heart glutathione peroxidase (GPX).
o Heart superoxide dimutase (SOD).
o Histopathological examination of heart.
Other data
| Title | A Pharmacological study of the effect(s) of Garlic and/or Ginseng on LPS induced Cardiotoxicity in Rats | Other Titles | رسالة فار ماكولوجية لدراسة تأثيرات الجنسنج و/ او الثوم على التسمم القلبى المحدث بالليبو بولى ساكارايد على الجرذان . | Authors | Eman Abd Al-Hameid Hussein Mahmmoud | Issue Date | 2010 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.