Evaluation of the Protective Role of Date (Phoenix dactylifera ) Against Flusilazole Fungicide Toxicity in Male Albino Rats

Abstract

Conazoles are a class of fungicides used to combat fungal growth in agriculture and as pharmaceutical products. Some members of this class have been shown to be hepatotoxic. This study was undertaken in a total number of one hundred and thirty adult male Wistar albino rats to investigate the toxic effects of flusilazole fungicide, by sub-chronic toxicity study at doses of 86.748 and 173.496 mg/kg b.w. which represented 1/20 and 1/10 of flusilazole LD50 respectively for consecutive five days per week for 90 days. As well as examine the possible protective role of aqueous extracts of date (Phoneix dactylifera L.) at doses of 6 and 12 g/kg body weight. against the haematotoxicity and hepatotoxicity induced by flusilazole, beside the oxidative stress, lipid profile, thyroid hormones levels and residual analysis of the tested fungicide in plasma and liver tissues .