Synthesis and Biological Evaluation of some Novel Quinoline derivatives

Abstract

Pyranoquinolinediones were synthesized and subjected to nitration followed by reduction to produce a novel 3-aminopyrano[3,2-c]quinoline-2,5- diones. Structure of compound 3c has been investigated and confirmed by 2D – NMR (gCOSY, gHSQC and gHMBC). Anti-oxidant and anti-cancer activity with molecular docking of 3-aminopyranoquinolinones has been evaluated. 3-amino-N- butyl-pyranoquinoline-2,5-diones precursor was utilized to obtain some novel heteroannulated pyrano[3,2-c]quinolone derivatives. These heteroannulation reactions afforded novel heterocyclic systems fused to pyranoquinolinone at face c, such as oxazole, triazine and pyrazine. A series of interesting Schiff bases and azo dyes derivatives of pyranoquinolinone were synthesized.

Keywords: Quinolinone, Pyranoquinolinone, Molecular docking, Heteroannulated tetracyclic systems, Oxazolo, antioxidant, anticancer, Spectral analysis.

Supervisors:

Prof. Dr. Mustafa Mohamed Ismail

Professor of Organic chemistry, Department of chemistry, Faculty of Education, Ain shams University

Prof. Dr. Alaa Alden Salem

Professor of analytical chemistry, Department of chemistry, Faculty of Faculty of Science – UAEU

Asst.Dr. Hany Mohamed Hassanin

Assistant Professor of Organic chemistry, Department of chemistry, Faculty of Education, Ain shams University

Asst.Dr. Ibram Mahmoud Abdou

Associate Professor of Organic chemistry, Department of chemistry, Faculty of Faculty of Science – UAEU

PhD Thesis- Organic Chemistry ii

Abdeltawab M.Saeed