Pharmacodynamic profile and haemodynamic effects of atracurium and cisatracurium in children with cyanotic congenital heart disease undergoing corrective open-cardiac surgery.

Abstract

Atracurium and Cisatracurium were studied in 40 children (Fallot's Tetralogy cases) undergoing corrective open cardiac surgery and non-cardiac children needing neuromuscular blocker for general surgery.Haemodynamic parameter included pulmonary artery pressure, blood pressure, heart rate, Qp/Qs ratio,and central venous pressure were measured to compare the effects of Atracurium and Cisatracurium in cardiac patients. Neuromuscular parameters (The first twitch amplitude depression of TOF ratio of 75%, 50%, 25%, onset, duration and clinical duration) of Atracurium and Cisatracurium in cardiac and non-cardiac children. There were haemodynamic stability with the use of Cisatracurium and prolongation of (The first twitch amplitude depression of TOF ratio of 75%, 50%, 25%, onset) in contrast to Atracurium, which was associated with haemodynamic instability due to release of histamine.