Antibiotic Susceptibility Pattern among Streptococcus pneumoniae Isolates

Abstract

Streptococcus pneumoniae is the leading cause of community-acquired pneumonia around the world. Severe pneumococcal disease is associated with high mortality in adults. Antimicrobial resistance of S. pneumoniae against the most commonly used antimicrobial drugs is increasing worldwide, principally affecting β-lactam, macrolide and sulfonamide sensitivity. β-lactam antibiotics, and penicillin in particular, are amongst the most widely used antimicrobial drugs for empirical treatment of pneumonia. There are reports worldwide about the increase in infections caused by S. pneumoniae resistant to antimicrobials. The aim of this work is to detect the antibiotic susciptibility pattern among S. pneumoniae isolates which recovered from clinical samples referred to the Central Microbiology Laboratory, Ain Shams University Hospitals. Detection of antimicrobial resistance of S. pneumoniae is fundamental to guide the empirical treatment of PID, as well as to encourage reflections to support immunization policies. This study was conducted on 50 S. pneumoniae isolates recovered from different clinical samples referred to the Central Microbiology Laboratory, Ain Shams University Hospitals, for routine culture and sensitivity .The isolates were subjected to confirmation of the