Central venous-to-arterial carbon dioxide difference as a predictor for mortality and morbidity in septic patient

Abstract

Sepsis is a life-threatening condition that arises when the body's response to infection injures its own tissues and organs. Sepsis causes millions of deaths globally each year and is the most common cause of death in people who have been hospitalized. Despite significant advances in understanding the pathophysiology of sepsis, mortality from the disease remains unacceptably high. Management of sepsis is largely supportive, which was given a huge importance to study factors that could predict outcome in patients suffering from sepsis and early recognition of signs of tissue hypoperfusion and their value during resuscitation.

The way to assess tissue perfusion during the resuscitation of septic patients is a current subject of research and debate. Venous oxygen saturation and lactate concentration have been the most frequently used criteria, though they involve known limitations. The venous-to-arterial difference of carbon dioxide (P (cv-a) CO2) is a parameter that can be used to indicate tissue perfusion, and its determination therefore may be useful in these patients.

Our study was conducted over 40 septic patients who me