Adenosin Deaminas activity in Serum and Pleural Fluid in Tuberculous and non – Tuberculous Patients

Abstract

The purpose of this study is to evaluate the usefulness of adenosine deaminase as a biomarker in diagnosis of TB pleural effusion. A prospective cross sectional study was conducted on forty patients with pleural effusion, selected from outpatient clinic and inpatient department of Abbasia Chest Hospital. They were classified into two groups: Group (A): patient with TB pleural effusion which included (20) patients. Group (B): patient with non TB pleural effusion which included (20) among them (12) patients with malignant pleural effusion; adenocarcinoma and mesothelioma, (6) patients for each, and (8) patients with non- malignant non-tuberculous pleural effusion (para pneumonic). All patients subjected to the following: 1- Full history taken. 2- Clinical examination 3- Laboratory examination including :- - liver function tests - kidney function tests - CBC - ESR - Sputum analysis for AFB - TST ( Tuberculin in skin test ) - Chest X – rays - ADA levels in serum and pleural effusion. - ADA index (effusion ADA/ADA serum)