Retrospective Analysis of Epidemiology and Clinical Outcome of Adult Glial Tumor Patients Treated in Clinical Oncology Department in Ain Shams University Hospitals in Egypt

Abstract

SUMMARY P rimary malignant brain tumors are the 17th most common cancer type worldwide, with more than 250 000 new cases diagnosed annualy and approximately 77% of these are gliomas which can occur any where in the central nervous system but primarily occur in the brain and arise in the glial tissue. Gliomas can be WHO grades I–IV based on malignant behavior. The most commonly occurring histologic types of gliomas in adults include astrocytoma (grades I–IV), oligodendroglioma (grades II–III), and oligoastrocytoma (grades II–III). Glioblastoma (WHO grade IV), the most common glioma in adults, accounts for 67% of all adult glioma diagnoses. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas.Also glioma varies with histopathology, patient age, gender, ethnicity, and geography. As a general rule, gliomas are more common in patients of older age, male gender, and Caucasian race. This study is a retrospective analysis carried out in clinical Oncology and Nuclear Medicine department, Faculty