Atherogenic Index of Plasma as a Predictor of Atherosclerosis in Hemodialysis Patients
Eman Magdy Abdellatif Hegazy;
Abstract
Nowadays, chronic kidney disease is recognized as a worldwide health problem with high morbidity and mortality rates.
CKD is recognized as an independent risk factor for numerous adverse health outcomes including cardiovascular disease which is the most common cause of morbidity and mortality in ESRD patients.
CVD manifestations in CKD patients are classified as myocardial (left ventricular hypertrophy and dilated cardiomyopathy) and vascular (vascular calcification, arteriosclerosis and atherosclerosis).
Atherosclerosis is the most common risk factor for CVD. It begins years before the development of any clinical manifestations. It is considered as a complex inflammatory fibroproliferative response developing due to accumulation of the atherogenic lipoproteins in the arterial intima.
The first structural change that can be detected in atherosclerosis is an increase in intima-media thickness of the artery.
Studies have shown that hemodialysis patients have advanced changes in the walls of their arteries, that present as increased IMT of the carotid and femoral arteries.
Carotid intima-media thickness is a widely available, safe, and reproducible measure obtained by B-mode ultrasound. In many studies, CIMT was proven to predict the existence of CVD. Increased CIMT was discovered to be a marker of diffuse atherosclerosis and so, CIMT was introduced as a golden parameter in detection of atherosclerosis even in its early stages.
It is well known that the concentrations of lipids (total cholesterol and TG) and their blood transporting lipoproteins (LDL-c, HDL-c and VLDL-c) are strongly related with the occurrence of atherosclerosis and CVD.
The atherogenic index of plasma, calculated as {log (TG/HDL-c)}, has recently started to gain attention as a significant indicator of the risk of atherosclerosis and CVD. It is even more suitable and statistically reliable than lipid concentrations in CVD risk prediction.
The aim of this study was to detect the correlation between CIMT and AIP in HD patients in particular which could result, if found positive, in using AIP as an easy to apply, inexpensive and most importantly a non-invasive
CKD is recognized as an independent risk factor for numerous adverse health outcomes including cardiovascular disease which is the most common cause of morbidity and mortality in ESRD patients.
CVD manifestations in CKD patients are classified as myocardial (left ventricular hypertrophy and dilated cardiomyopathy) and vascular (vascular calcification, arteriosclerosis and atherosclerosis).
Atherosclerosis is the most common risk factor for CVD. It begins years before the development of any clinical manifestations. It is considered as a complex inflammatory fibroproliferative response developing due to accumulation of the atherogenic lipoproteins in the arterial intima.
The first structural change that can be detected in atherosclerosis is an increase in intima-media thickness of the artery.
Studies have shown that hemodialysis patients have advanced changes in the walls of their arteries, that present as increased IMT of the carotid and femoral arteries.
Carotid intima-media thickness is a widely available, safe, and reproducible measure obtained by B-mode ultrasound. In many studies, CIMT was proven to predict the existence of CVD. Increased CIMT was discovered to be a marker of diffuse atherosclerosis and so, CIMT was introduced as a golden parameter in detection of atherosclerosis even in its early stages.
It is well known that the concentrations of lipids (total cholesterol and TG) and their blood transporting lipoproteins (LDL-c, HDL-c and VLDL-c) are strongly related with the occurrence of atherosclerosis and CVD.
The atherogenic index of plasma, calculated as {log (TG/HDL-c)}, has recently started to gain attention as a significant indicator of the risk of atherosclerosis and CVD. It is even more suitable and statistically reliable than lipid concentrations in CVD risk prediction.
The aim of this study was to detect the correlation between CIMT and AIP in HD patients in particular which could result, if found positive, in using AIP as an easy to apply, inexpensive and most importantly a non-invasive
Other data
| Title | Atherogenic Index of Plasma as a Predictor of Atherosclerosis in Hemodialysis Patients | Other Titles | مؤشر البلازما لتصلب الشرايين كدلالة للتنبؤ بتصلب الشرايين في مرضى الغسيل الكلوي | Authors | Eman Magdy Abdellatif Hegazy | Issue Date | 2017 |
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