Effects of Soy Isoflavones and Tamoxifen on The Structure of Thyroid Gland of Adult Female Versus Male Albino Rats
Mary Refaat Isaac;
Abstract
The present work investigated the effects of soy
isoflavones, a naturally occurring selective estrogen receptor
modulator (SERM), and tamoxifen, a synthetic SERM, on the
structure of thyroid gland of both male and female adult albino
rats.
Sixty adult albino rats, thirty males and thirty females, were used in this study. Animals were divided into three groups each containing ten males and ten females. Rats in group I were given the vehicles of the drugs and were used as control. Animals in group II were given soy isoflavones at a dose of 500μgm/gm for three months and those in group III were given tamoxifen at a dose of 200 μg /kg tamoxifen once per day for four weeks. At the end of the experiment, animals were sacrificed; thyroid glands were excised, processed and examined using light and electron microscopes. Morphometric studies were also done.
Our results showed that male rats given soy isoflavones
isoflavones, a naturally occurring selective estrogen receptor
modulator (SERM), and tamoxifen, a synthetic SERM, on the
structure of thyroid gland of both male and female adult albino
rats.
Sixty adult albino rats, thirty males and thirty females, were used in this study. Animals were divided into three groups each containing ten males and ten females. Rats in group I were given the vehicles of the drugs and were used as control. Animals in group II were given soy isoflavones at a dose of 500μgm/gm for three months and those in group III were given tamoxifen at a dose of 200 μg /kg tamoxifen once per day for four weeks. At the end of the experiment, animals were sacrificed; thyroid glands were excised, processed and examined using light and electron microscopes. Morphometric studies were also done.
Our results showed that male rats given soy isoflavones
Other data
| Title | Effects of Soy Isoflavones and Tamoxifen on The Structure of Thyroid Gland of Adult Female Versus Male Albino Rats | Authors | Mary Refaat Isaac | Issue Date | 2013 |
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