Levels of Plasma Carnitine and Preeclampsia
Hanaa Gamal Soliman;
Abstract
Preeclampsia is a pregnancy-specific disorder characterized by hypertension and excess protein excretion in the urine (Pennington et al., 2012). It occurs after the 20thweek of gestation (Sabine et al., 2010).
Preeclampsia (PE) affects 5% of pregnancies and is a significant contributor to maternal mortality and morbidity .The effects of PE extend beyond pregnancy, with associated risk of type II diabetes, hypertensive disorders,and coronary artery disease in later life (Anthony et al., 2011).
L-carnitine is a natural amino acid that plays an important role in fatty acid metabolism (Orkut et al., 2013).
L-carnitine is intrinsically involved in mitochondrial metabolism and function as it plays a key role in fatty acid oxidation and energy metabolism. In addition to the transportation of free fatty acids across the inner mitochondrial membrane, L-carnitine modulates their oxidation rate and is involved in the regulation of vital cellular functions such as apoptosis (Santica et al., 2013).
Plasma carnitine analysis is an important diagnostic tool for recognizing deficiencies in fatty acid oxidation (Osmanağaoğlu et al., 2011).
This study is a case control study which was conducted in the Antenatal Clinic, Antenatal Department and the Casualty Room in Ain Shams University Maternity Hospital from August 2013 to December 2013. This study was approved by Ethical Committee of Ain Shams University Maternity Hospital to compare the total plasma carnitine level in preeclampsia and in normal pregnancy. It included eighty pregnant women aged 20 - 40 years, Primigravida or multigravida 28 - 40 weeks of gestation in a previously healthy ones. Excluded were multiple pregnancies, women with preexisting hypertension, diabetes, renal dysfunction and immune disease divided into two groups:
Group A: Included 40 pregnant women fulfilling the criteria of preeclampsia according to American College of Obstetrics and Gynecology 2010.
Group B: Included 40 healthy pregnant women without hypertension or proteinuria matched for gestational age.
Total plasma carnitine level was measured for each woman.
Preeclampsia (PE) affects 5% of pregnancies and is a significant contributor to maternal mortality and morbidity .The effects of PE extend beyond pregnancy, with associated risk of type II diabetes, hypertensive disorders,and coronary artery disease in later life (Anthony et al., 2011).
L-carnitine is a natural amino acid that plays an important role in fatty acid metabolism (Orkut et al., 2013).
L-carnitine is intrinsically involved in mitochondrial metabolism and function as it plays a key role in fatty acid oxidation and energy metabolism. In addition to the transportation of free fatty acids across the inner mitochondrial membrane, L-carnitine modulates their oxidation rate and is involved in the regulation of vital cellular functions such as apoptosis (Santica et al., 2013).
Plasma carnitine analysis is an important diagnostic tool for recognizing deficiencies in fatty acid oxidation (Osmanağaoğlu et al., 2011).
This study is a case control study which was conducted in the Antenatal Clinic, Antenatal Department and the Casualty Room in Ain Shams University Maternity Hospital from August 2013 to December 2013. This study was approved by Ethical Committee of Ain Shams University Maternity Hospital to compare the total plasma carnitine level in preeclampsia and in normal pregnancy. It included eighty pregnant women aged 20 - 40 years, Primigravida or multigravida 28 - 40 weeks of gestation in a previously healthy ones. Excluded were multiple pregnancies, women with preexisting hypertension, diabetes, renal dysfunction and immune disease divided into two groups:
Group A: Included 40 pregnant women fulfilling the criteria of preeclampsia according to American College of Obstetrics and Gynecology 2010.
Group B: Included 40 healthy pregnant women without hypertension or proteinuria matched for gestational age.
Total plasma carnitine level was measured for each woman.
Other data
| Title | Levels of Plasma Carnitine and Preeclampsia | Other Titles | مستوى الكارنتين فى بلازما مرضى ما قبل تسمم الحمل | Authors | Hanaa Gamal Soliman | Issue Date | 2014 |
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