Advanced Oxidation Protein Products as a Novel Marker for oxidative stress in Neonatal Respiratory Distress Syndrome

Abstract

R espiratory distress syndrome is an acute lung disease of premature infant caused by inadequate amounts of surfactant. Decreased surfactant results in insufficient surface tension in the alveolus during expiration, leading to atelectasis, decreased gas exchange, severe hypoxia and acidosis. Oxidative stress occurs as a result of increased activity of free radical–producing enzymes, decreased activity of free radical–removing enzymes, and insufficient levels of antioxidants. Preterm neonates suffer RDS due to the rapid formation of the oxygen reactive species, which surpasses the detoxification capacity of anti-oxidative defense system. The high chemical reactivity of free radical leads to damage to a variety of cellular macro molecules including proteins. The aim of study was to evaluate oxidant-antioxidant balance in preterm neonates with RDS by measuring total antioxidant capacity and malondialdehyde as well as the novel marker for protein oxidation “advanced oxidation protein products” in day 1 and day 3 of life. This study comprised 80 preterm neonates less than 34 weeks of gestational age, admitted at Neonatal Intensive Care Unit, Ain Shams University Hospitals. They were 40 preterm neonates with RDS and 40 preterm neonates without RDS.