Maternal Serum Homocystine in Preeclampsia

Abstract

SUMMARY AND CONCLUSION T he aim of this study was to estimate maternal serum homocysteine levels in patients with preeclampsia compared to normotensive pregnant women. The studied was carried out at the Department of Obstetric and Gynecology in Ain Shams University, we recruited 75 pregnant women after 28 weeks of gestation and they were classified into 3 groups: Group 1: 25 normal pregnant women serving as controls, Group 2: 25 women diagnosed with mild pre-eclampsia from 28 weeks of gestation till term, Group 3: 25 women diagnosed with severe pre-eclampsia from 28 weeks of gestation till term. The exclusion criteria for this study were chronic hypertension, collagen vascular disorders, liver disease, renal disease, thyroid disease, tobacco abuse. All groups were subjected to: informative consent, detailed history and complete physical examination, assessment of height and weight, blood pressure was measured in a semi-recumbent position with a standard mercury sphygmo-manometer, complete blood picture, creatinine, ALT, AST and PTT, assessment of serum homocysteine level. All data were statically analized and tabulated and the result data show that: There was no statistical difference between control, mild preeclampsia and severe preeclampsia groups regarding maternal age, gestational age, weight, height, BMI, Hemoglobin, Platelets, PTT and creatinine. There was statistical difference between control, mild preeclampsia and severe preeclampsia groups regarding systolic and diastolic blood pressure, ALT and AST. There was statistical difference between control, mild preeclampsia and severe preeclampsia groups regarding serum homocysteine level which mean was 6.1±0.5 µmol/L for control group while in mild preeclampsia group it was 9±0.5 µmol/L and 17.3±0.1 µmol/L in severe preeclampsia group. In the current study there is no correlation between maternal serum homocysteine level and any of the studied parameters. In conclusion, from this study it can be concluded that hyperhomocysteinemia may play a role in the pathogenesis of preeclampsia and the level of maternal serum homocysteine is related to the severity of preeclampsia.