A SSESSMENT OF BLEEDING TENDENCY & PLATELET ACTIVATION IN THALASSEMIC CHILDREN
Hayam Mohamed Abd EI-All;
Abstract
Standard of care for thalassemic patients have improved in recent years, resulting in almost doubling of the average life expectancy. As a consequence, additional previously unsctibed complications are new being recognized.
In pmticular, profound hemostatic changes have been observed in patients with thalassemia major or thalassemia intennedia. These hemostatic changes may be in the fonn of thrombotic or hemonhagic events. To study hemonhagic events we assessed platelet aggregation to ADP atld Ristocetin in thalassemic children presenting with epistaxis and compare the results to group of nonnal children in the same age a sex group presented to E.N.T. clinic by recunent epistaxis. Control group had no bleeding tendency due to haematological condition.
Both cases and control were subjected to complete clinical examination, Full Blood Count (FBC.), liver enzymes (AST, ALT), PC,PT,PTT m1d serum fenitin. In addition, platelet aggregation to ADP atld ristocetin were assessed for both cases and control too. The levels of plalelet aggregation to ADP and ristoctein found to be statistically lower in thalassemic children as compared to contTOL
The results were positively con•elated with ALT, which indicate that liver status is contlibuting factor in bleeding tendency in thalassemic cases.
In conclusion, bleeding tendency in thalassemic patients can be ath•ibuted to a defect 111 platelet aggregation namely platelet hypoaggregation. However, hepatic dysfunction associated with the disease can be a conn•ibuting factor as well.
Thalassemic children with bleeding tendency should receive vitatnin
K supplementation to compensate for hepatic synthesis defect.
In pmticular, profound hemostatic changes have been observed in patients with thalassemia major or thalassemia intennedia. These hemostatic changes may be in the fonn of thrombotic or hemonhagic events. To study hemonhagic events we assessed platelet aggregation to ADP atld Ristocetin in thalassemic children presenting with epistaxis and compare the results to group of nonnal children in the same age a sex group presented to E.N.T. clinic by recunent epistaxis. Control group had no bleeding tendency due to haematological condition.
Both cases and control were subjected to complete clinical examination, Full Blood Count (FBC.), liver enzymes (AST, ALT), PC,PT,PTT m1d serum fenitin. In addition, platelet aggregation to ADP atld ristocetin were assessed for both cases and control too. The levels of plalelet aggregation to ADP and ristoctein found to be statistically lower in thalassemic children as compared to contTOL
The results were positively con•elated with ALT, which indicate that liver status is contlibuting factor in bleeding tendency in thalassemic cases.
In conclusion, bleeding tendency in thalassemic patients can be ath•ibuted to a defect 111 platelet aggregation namely platelet hypoaggregation. However, hepatic dysfunction associated with the disease can be a conn•ibuting factor as well.
Thalassemic children with bleeding tendency should receive vitatnin
K supplementation to compensate for hepatic synthesis defect.
Other data
| Title | A SSESSMENT OF BLEEDING TENDENCY & PLATELET ACTIVATION IN THALASSEMIC CHILDREN | Other Titles | دراسة القابلية للنزف ونشاط الصفائح الدموية في الأطفال مرضي انيميا البحر الأبيض المتوسط | Authors | Hayam Mohamed Abd EI-All | Issue Date | 2005 |
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