Effects of Tumor Necrosis Factor Inhibitor on the Regeneration of Injured Sciatic Nerve of Albino Rat

Abstract

Despite the regenerative potential of the peripheral nervous system, severe nerve lesions lead to loss of target-organ innervation, making complete functional recoverya challenge. The present work aimed to investigate the effect of tumor necrosis factor inhibitor on the regeneration of injured sciatic nerve. Ninety adult male albino rats were used. Animals were subdivided into fifteen groups. The injured groups included thirty rats divided into 5 groups. Sciatic nerve injury was done by transection followed by end to end neurorrophy. The treated groups included thirty rats divided into 5 groups. Sciatic nerve injury was done by transection followed by end to end neurorraphy then followed again by intraperitoneal of tumor necrosis factor inhibitor. The dose was calculated as 6mg per kg. The last thirty rats were the sham operated groups. Decapitation of the rats was done. The sciatic nerves were dissected from each rat. This procedure took place after 2days, 1 week,4 weeks,8weeks and 12 weeks from the injury.