Role of Diffusion Tensor Imaging and Positron Emission Tomography in Assessment of Epilepsy

Abstract

Modern neuroimaging is central to the assessment of patient with epilepsy and has dramatically modified their management because in patient with intractable epilepsy surgical treatment with removal of the epileptogenic lesion is vastly superior to medical treatment. Therefore, visualization of lesions that give rise to focal epilepsy and identification of patient who are sensitive for surgical treatment are important goals in imaging of epilepsy. Magnetic resonance imaging (MRI) can identify substrate underlying epilepsy, and guide clinicians in the determination of treatment and prognosis. The use of computed tomography (CT) has been diminished by the superior sensitivity and specificity of MRI. Recent imaging modalities such as functional MRI, MRS, DTI and radioisotope of the brain (such as PET) are used in the assessment of epileptic patients to help in localization of epileptic focus. Diffusion tensor imaging and tractography provide further for imaging patient with epilepsy, the interpretation of inter, peri, and post ictal diffusion images is complex but has the potential to improve understanding of seizure physiology Summary And Conclusion 149 and o have some localizing value in patient with focal epilepsy . Diffusion MRI and tractography are new MRI methods , relying on the displacement properties of the water molecules in the brain that are entering research and clinical activity at a tremendous pace .The Improvement of imaging of fiber crossing and the time necessary to causally to obtain a good quality image allows very sensitive detection of structure and functional abnormalities as well as the representation of nervous fibers in the brain