Analytical Study of Certain Thiazide and Thiazide-Like Diuretics
Mahmoud Ahmad Omar Hassan;
Abstract
In this thesis, simple, reliable and sensitive spectrophotometric and spectrofluorimetric methods were developed for the determination of eight thiazide and thiazide-like diuretics namely bendroflumethiazide, benzthiazide, hydrochlorothiazide, hydroflumethiazide, chlorthalidone, clopamide, indapamide and xipamide.
The thesis falls into six main parts
The first part : General introduction
Includes gen ral introduction about thiazide and thiazide-like diuretis, information about chemical structure, pharmacokinetics, mechanism of action and therapeutic indications.
Also this part comprises a literature review of the official and reported analytical methods for the determination of the studied drugs. These methods were classified into titrimetric, spectrophotometric, spectrofluorimetric, chromatographic, elctrophoretic and electrochemical methods. In this part also the scope of the work was explained.
The second part : Include the reaction of bendroflumethiazide,
benzthiazide, hydrochlorothiazide, hydroflumethiazide, chlorthalidone, clopamide, indapamide and xipamide with hydroxylamine to form hydroxamates of these compounds, the resulting hydroxamates were chelated with ferric chloride in acid medium. This part comprises two sections.
The Experimental section includes the laboratory experimental informations about all the instruments, drugs, reagents, solutions, pharmaceutical formulations and procedures used in this method. In addition, methods used for the investigation of the reaction mechanism wass studied.
The second section (Results and discussion) includes the results obtained from the analysis of the studied thiazide and thiazide-like diuretis by the
The thesis falls into six main parts
The first part : General introduction
Includes gen ral introduction about thiazide and thiazide-like diuretis, information about chemical structure, pharmacokinetics, mechanism of action and therapeutic indications.
Also this part comprises a literature review of the official and reported analytical methods for the determination of the studied drugs. These methods were classified into titrimetric, spectrophotometric, spectrofluorimetric, chromatographic, elctrophoretic and electrochemical methods. In this part also the scope of the work was explained.
The second part : Include the reaction of bendroflumethiazide,
benzthiazide, hydrochlorothiazide, hydroflumethiazide, chlorthalidone, clopamide, indapamide and xipamide with hydroxylamine to form hydroxamates of these compounds, the resulting hydroxamates were chelated with ferric chloride in acid medium. This part comprises two sections.
The Experimental section includes the laboratory experimental informations about all the instruments, drugs, reagents, solutions, pharmaceutical formulations and procedures used in this method. In addition, methods used for the investigation of the reaction mechanism wass studied.
The second section (Results and discussion) includes the results obtained from the analysis of the studied thiazide and thiazide-like diuretis by the
Other data
| Title | Analytical Study of Certain Thiazide and Thiazide-Like Diuretics | Other Titles | دراسة تحليلية لبعض مدرات البول من مجموعة مشتقات الثيازيد ومثيلاتها | Authors | Mahmoud Ahmad Omar Hassan | Issue Date | 2005 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| Mahmoud Ahmad Omar Hassan.pdf | 1.5 MB | Adobe PDF | View/Open |
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