RANTES IN NON HEMOLYTiC TRANSFUSION REACTIONS AFTER PLATELET TRANSFUSION
Nermein Gamal El Deen Abd El Hameed Anter;
Abstract
Platelet use has increased markedly in recent years. It is indicated in cases of bone marrow failure, immune thrombocytopenia, and bleeding in functional platelet defects.
Among problems that are associated with platelet transfusion therapy; a major problem in patients who receive multiple platelet transfusions is febrile nonhemolytic transfusion reactions (FNHTRs) that complicate nearly up to 20% of platelet transfusions.
It has been recently reported that platelet derived biologic response biologic response modifiers (BRMs) including RANTES accumulate in platelet components during storage and may play a causative role in nonhemolytic febrile transfusion reactions.
This study showed the role of RANTES accumulation in platelet units, and the in vivo development of nonhemolytic transfusion reactions in transfused patients as well as its correlation to duration of storage.
The study was done on 60 patients receiving platelet transfusion for vanous causes that can be divided into oncological diseases including NonHodjkin's Lymphoma, Acute myeloid Leukemia and Thrombocytopenia induced by chemotherapy. And nononcological diseases including aplastic anemia, thrombasthenia and Fanconi's anemia.
The patients' age ranged between 7 months and 16 years with a mean of 8 ± 4.2 years. 57% of them were males and 43% were females.
Among problems that are associated with platelet transfusion therapy; a major problem in patients who receive multiple platelet transfusions is febrile nonhemolytic transfusion reactions (FNHTRs) that complicate nearly up to 20% of platelet transfusions.
It has been recently reported that platelet derived biologic response biologic response modifiers (BRMs) including RANTES accumulate in platelet components during storage and may play a causative role in nonhemolytic febrile transfusion reactions.
This study showed the role of RANTES accumulation in platelet units, and the in vivo development of nonhemolytic transfusion reactions in transfused patients as well as its correlation to duration of storage.
The study was done on 60 patients receiving platelet transfusion for vanous causes that can be divided into oncological diseases including NonHodjkin's Lymphoma, Acute myeloid Leukemia and Thrombocytopenia induced by chemotherapy. And nononcological diseases including aplastic anemia, thrombasthenia and Fanconi's anemia.
The patients' age ranged between 7 months and 16 years with a mean of 8 ± 4.2 years. 57% of them were males and 43% were females.
Other data
| Title | RANTES IN NON HEMOLYTiC TRANSFUSION REACTIONS AFTER PLATELET TRANSFUSION | Other Titles | مادة رانتس فى المضاعفات غير التكسيرية المصاحبة لنقل الصفائح الدموية | Authors | Nermein Gamal El Deen Abd El Hameed Anter | Issue Date | 2001 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.