Studying the effect of increasing the doses of Magnesium Sulphate as an adjuvant to Bupivacaine in Supraclavicular Brachial plexus block

Abstract

Brachial plexus is a network of nerves that arises from the neck passing through the axilla to supply the whole upper limb with motor and sensory supply. Our target in upper limb surgeries is to block this plexus using local anesthetics. Various adjuvants have been mixed with local anesthetics (LAs) for peripheral nerve blocks (PNBs). These drugs usually hasten the onset of action and prolong the duration of analgesia. They may also allow for a reduction in the total dose of LA used and related side effects. Since the introduction of magnesium sulfate (MgSO4) asan N-Methyl-D-aspartate(NMDA) receptors antagonist, its role has been evaluated for the analgesic properties in anesthesia practice.MgSO4 is a promising agent as an adjuvant in to local anesthetics in peripheral nerve blocks. The aim of the present study was to compare the effects of adding either 200 or 600 mg of MgSO4 to bupivacaine in ultrasound-guided supraclavicular nerve block in upper limb surgeries. The comparison included the onset, the duration of the sensory and motor blocks, the duration of analgesia of the block, their effects on the postoperative analgesic