Outcome Of Trans- Arterial Chemo Embolization (TACE) In Hepatocellular Carcinoma Patients With Partial Portal Vein Thrombosis

Abstract

Liver cancer is the sixth most common cancer and the third cause of cancer related death and accounts for 7% of all cancers. HCC represents more than 90% of primary liver cancers and is a major global health problem . Portal vein thrombosis is a common complication of HCC, which is associated with a poor prognosis. Approximately 10%-40% patients with HCC have PVT at the time of diagnosis,and approximately 35%-44% will be found to have PVT at the time of death or liver transplant . All included patients were subjected to: 1. Complete history taking and thorough clinical examination. 2. ESR 3. Laboratory investigations: Complete blood count (CBC), liver profile, renal profile, hepatitis markers, serum alpha-fetoprotein. 4. Imaging studies : Abdominal Ultrasonography, Doppler US and Abdominal Triphasic Spiral Computed Tomography.

5. Quality of life assessment by (QLQ)-C30 Arabic edition. Post-Treatment Follow-Up Studies: All patients were subjected to follow up at 1, 3 months after the maneuver and were subjected to the following: a. Full clinical examination, b. Liver function tests, α fetoprotein c. Spiral CT of abdomen or MRI with d. ontrast to assess tumor response e. Quality of life assessment by (QLQ)-C30 Arabic edition. Results: Safety of the maneuver: No procedure-related mortality occurred among the 30 patients No serious complications related to the maneuver. 16 patients developed ascites which was medically controlled,3 patients developed jaundice and 1 patient had hepatic encephalopathy 3 weeks after intervention .