MDRI GENE AND lTS PRODUCT (P – GLYCOPROTEIN): DETECTION AND PROGNOSTIC SIGNIFICANCE IN AML
Menat Allah Kamal EI-Deen Abo El Azaiem;
Abstract
AML is a clonal, malignant disease of hematopoietic tissue that is characterized by the proliferation of leukemic cells, principally in the
marrow and impaired production of normal blood cells.
Multidrug resistance is the phenomenon in which exposure of tumour cells to a single cytotoxic agent results in cross resistance to other structurally unrelated classes of cytotoxic agents.
Drug resistance, frequent relapses and failure of induction of remission are common problems encountered during treatment of acute myeloic! leukemia. In 1976, Juliano and Ling de cribed a membrane transport protein which they called "P-glycoprotein". It was speculated that P-glycoprotein decreases the access of drugs to the cytoplasm of cancer cells and thus, it is responsible for the problem of drug resistance.•
Genomic analysis established that, in humans there are three closely related genes, the MDRl, MDR2 and MDR3. Until now, MDRl is the only one which is highly incriminated in the development ofmultidrug resistance.
marrow and impaired production of normal blood cells.
Multidrug resistance is the phenomenon in which exposure of tumour cells to a single cytotoxic agent results in cross resistance to other structurally unrelated classes of cytotoxic agents.
Drug resistance, frequent relapses and failure of induction of remission are common problems encountered during treatment of acute myeloic! leukemia. In 1976, Juliano and Ling de cribed a membrane transport protein which they called "P-glycoprotein". It was speculated that P-glycoprotein decreases the access of drugs to the cytoplasm of cancer cells and thus, it is responsible for the problem of drug resistance.•
Genomic analysis established that, in humans there are three closely related genes, the MDRl, MDR2 and MDR3. Until now, MDRl is the only one which is highly incriminated in the development ofmultidrug resistance.
Other data
| Title | MDRI GENE AND lTS PRODUCT (P – GLYCOPROTEIN): DETECTION AND PROGNOSTIC SIGNIFICANCE IN AML | Other Titles | جين (MDR 1 ) وناتجه ( P – Gp ) ، قياسهم وتحديد قيمتهم التنبؤية فى حالات سرطان الدم النخاعى الحاد | Authors | Menat Allah Kamal EI-Deen Abo El Azaiem | Issue Date | 2002 |
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