Discovery of Certain Organic Compounds as Targeted Anticancer Agents

Abstract

Cancer, or malignant tumor, is a myriad of diseases involving abnormal cell growth with the potential to invade or metastasize to other parts of the body. therefore, there is a need for newer treatment strategies with novel drugs acting at different pathways for treatment of malignancies. Targeted therapies act by blocking essential biochemical pathways or mutant proteins that are required for tumour cell growth and survival. In the past few decades, protein kinases has drawn much attention as being of the most important drug targets for treatment of many diseases; especially cancer. Since, dysregulation and mutation in this family of ezymes play causual role in the development and maintenance of different types of cancer. Particularly, Vascular endothelial growth factor receptor-2 (VEGFR2) which is implemented in the maintanence of angiogenesis. Angiogensis; the growth of new blood vessels; is considered one of the important hallmarks of cancer. Hence there is a growing interest in VEGFR2 inhibition and its therapeutic implementation in cancer treatment in light of its unique ability to regulate cancer cell proliferation and metastasis through inhibiting angiogenesis, eventually leading to death of tumor cells.