Retrospective Study Of Survival Benefit Of Second Line Chemotherapy In Adult Soft Tissue Sarcomas

Abstract

In summary, the current series of STS in adult involved 34 patients with a mean age of 40.9±13.4 years and male predominance (67.6%). The extremities were affected in 47% of cases. Four uterine leiomyosarcomas and 3 cases involving the chest wall were found.

There was an obvious histological diversity where synovial sarcoma was the most frequent type (29.4%) followed by liposarcoma and spindle cell sarcoma. Higher tumor grade was more common (59%) and distant metastases was detected in 18 patients (53%); more commonly with grade 3disease. Surgical treatment was adopted in 29 patients including only 2 amputations. Surgical margin was positive in 18/29 patients (62.1%). Palliative radiotherapy was used in 15 patients (44.1%). The most commonly used 1st line chemotherapy protocol was Ifosfamide + Adriamycin. Response after surgery and 1st line CTH was complete or partial remission in only 50% cases. Remission rate was apparently higher in patients with negative margin.