DIAGNOSTIC SIGNIFICANCE OF FASTING PLASMA GLUCOSE VERSUS POST-PRANDIAL PLASMA GLUCOSE IN CORRELATION TO LIVER FUNCTION TESTS IN TYPE 2 DIABETES MELLITUS

Abstract

Diabetes mellitus is a hterogenous syndrome the pathophysiology of type II diabetes mellitus is either related to the pattern of insulin secretion and action or overproduction of hepatic glucose or combination of both. Post­ prandial plasma glucose is greatly correlated to the diet and insulin action pattern while and the fasting plasma glucose is correlated to hepatic glucose production.

• A 51 of type II diabetic patients attending Kasr EI-Aini hospital, were subjected to thorough clinical examination and a group of laboratory investigation including.

Fasting and 2 hours post-prandial blood glucose liver function tests (SGOT, SGPT, alkaline phosphatase, serum albumin, prothrombin concentration and serum billirubin), Fasting and 2 hours post-prandial serum insulin level:

Results of the present work showed that fasting and post-prandial blood glucose and insulin and liver function tests are higher in patients than in control group. Fasting and post-prandial blood glucose and insulin higher in patients with abnormal liver function tests and patients with hepatomegly than in patients with normal liver function tests and without hepatomegly.

Patients with hepatomgaly and/or abnormal liver function tests were found to have a higher fasting and post-prandial glucose while those without hepatomegly and with normal liver function tests have an acceptable fasting blood glucose so presence of abnormal liver function tests and/or hepatomegally seems to add more to the insulin resistance and aggravating hyperglycemia.