Comparative study of Urinary neutrophil gelatinase-associated lipocalin and Interlukin- 18 versus serum creatinine in early detection o acute kidney injury in critically ill patients

Abstract

Acute kidney injury (AKI) is a common ICU problem with a variety of pathophysiological patterns. It has devastating consequences on patients' mortality and morbidity while its management mainly depends on prevention. Although the use of a unified diagnostic criteria was a progress in defining the syndrome, many concerns were associated with its dependence on serum creatinine and urine output. These concerns led to the continuous search for a reliable kidney injury biomarker. Urine neutophil associated lipocalin (uNGAL) was extensively tested to diagnose AKI in several patients' subtypes including patients in the ICU and patients with sepsis. It is a molecule that is increased in response to inflammation to