Clinical Utility of Third Trimester’s Endocan-1 Levels in Pregnant Women with Diabetes Mellitus

Abstract

DM in pregnancy has a great impact on the mother and fetus. Although, the pathogenesis is not fully understood, it is now accepted that vascular endothelial dysfunction as well as inflammation are important in the pathophysiology of the disease. Endocan-1, a proteoglycan, secreted from vascular endothelium mostly activated endothelium. It is increased in inflammation, sepsis, tumors, PE, HTN, CKD, CVD and DM. The aim of the present study was to assess serum endocan in a group of pregnant females with diabetes and the probable relationship between third trimester’s serum endocan-1 levels and glycemic control monitored by HbA1c and OGTT as well as diabetes-related complications in pregnant women with diabetes . Based on these facts,this study was conducted on eighty (80