CA-125 and Severity of Preeclampsia
Marwa Mohamed Ibrahim;
Abstract
P
reeclampsia is a serious disease in the whole world. It is one of the important causes of maternal and neonatal morbidity and mortality. Most patients present by resistant sudden hypertension, edema, proteinuria, and in sever cases impaired liver and renal functions and also visual disturbances.
Many theories have attempted to explain the mechanism of preeclampsia, but its exact pathogenesis remains unclear. Reduced uterine prfusion pressure(RUPP) is one of the most impatant theories that start placental ischemia leading to acascade of numerous inflammatory mediators. And a recent theory about abnormal implantation which leads to placental hypoxia leading to release of inflammatory mediators such as sFlt-1and PlGF which act on the vascular endothelium causing altered vascular reactivity and decreased intravascular volume. Another theory about abnormal immunological tolerance may provoke an immune response against the placenta (AT1-AA)and even paternal antigens of the fetus. The genetic theory is also possible due to increased incidence of preeclampsia in women with family history of the disease but still under research.
Various methods have been proposed for prediction of preeclampsia as: family history, previous history of preeclampsia, parity, Doppler ultrasound of uterine artery, serum uric acid, urinary calcium/creatinine ratio, PAPP-A, sFlt-1 and VEGF but still there is the need for the development of a more reliable and cost-effective method for disease prediction.
CA-125 is defined first as a tumor marker specially with ovarian cancer.Recently elevated serum levels of CA-125 are found in physiological conditions as menstruation and pregnancy and in pathological conditions as endometriosis, fibroid, pelvic inflammatory disease, ovarian hyperstimulation syndrome, end-stage liver disease and a variety of gynecological and non-gynecological neoplasms.
In pregnancy, serum CA-125 levels are increased in early pregnancy and immediately after birth implicating the disintegration of the maternal decidua (i.e., blastocyst implantation and placental separation) as a possible source of the tumor marker elevation.
This study was conducted at Ain Shams University Maternity Hospital to assess free serum CA-125in pregnant women with preeclampsia in the third trimester to find out possible relation between the level of CA-125and severity of preeclampsia.
reeclampsia is a serious disease in the whole world. It is one of the important causes of maternal and neonatal morbidity and mortality. Most patients present by resistant sudden hypertension, edema, proteinuria, and in sever cases impaired liver and renal functions and also visual disturbances.
Many theories have attempted to explain the mechanism of preeclampsia, but its exact pathogenesis remains unclear. Reduced uterine prfusion pressure(RUPP) is one of the most impatant theories that start placental ischemia leading to acascade of numerous inflammatory mediators. And a recent theory about abnormal implantation which leads to placental hypoxia leading to release of inflammatory mediators such as sFlt-1and PlGF which act on the vascular endothelium causing altered vascular reactivity and decreased intravascular volume. Another theory about abnormal immunological tolerance may provoke an immune response against the placenta (AT1-AA)and even paternal antigens of the fetus. The genetic theory is also possible due to increased incidence of preeclampsia in women with family history of the disease but still under research.
Various methods have been proposed for prediction of preeclampsia as: family history, previous history of preeclampsia, parity, Doppler ultrasound of uterine artery, serum uric acid, urinary calcium/creatinine ratio, PAPP-A, sFlt-1 and VEGF but still there is the need for the development of a more reliable and cost-effective method for disease prediction.
CA-125 is defined first as a tumor marker specially with ovarian cancer.Recently elevated serum levels of CA-125 are found in physiological conditions as menstruation and pregnancy and in pathological conditions as endometriosis, fibroid, pelvic inflammatory disease, ovarian hyperstimulation syndrome, end-stage liver disease and a variety of gynecological and non-gynecological neoplasms.
In pregnancy, serum CA-125 levels are increased in early pregnancy and immediately after birth implicating the disintegration of the maternal decidua (i.e., blastocyst implantation and placental separation) as a possible source of the tumor marker elevation.
This study was conducted at Ain Shams University Maternity Hospital to assess free serum CA-125in pregnant women with preeclampsia in the third trimester to find out possible relation between the level of CA-125and severity of preeclampsia.
Other data
| Title | CA-125 and Severity of Preeclampsia | Other Titles | قيمة قياس CA-125 وشدة تسمم الحمل | Authors | Marwa Mohamed Ibrahim | Issue Date | 2017 |
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