Study of cerebral circulation hemodynamics in prevalent hemodialysis patients

Abstract

In the current study, fifty prevalent HD patients were included from El Sahel teaching hospital dialysis units. All patients were on regular HD thrice weekly for at least 6 month, each dialysis session lasted four hours with clinically stable condition. In our study we exclude patients with cerebrovascular insult, active collagen disease, diabetes mellitus, uncontrolled hypertension, severe anemia ≤ 8 g/dl, decompensated chronic liver disease , heavy smokers and active inflammation. All patients were subjected to clinical examination; Fasting serum samples were obtained. All biochemical blood samples were collected before the mid-week HD session and before heparin administration. Laboratory investigations included: Hemoglobin level, urea (pre& post dialysis), creatinine, Urea reduction ratio (URR), albumin, calcium, phosphorus, PTH, CRP titer, lipid profile, and HCV Ab were done. An informed detailed consent was taken from the patients before the start of the study. Cerebral circulation was assessed by measuring mean flow velocity in middle cerebral artery and posterior cerebral artery in non-dialysis day using trans cranial Doppler sonography machine. This study included 18 (32%) female patients and 27 (68%) male patients with mean of age 43.4 years and range from 22-62 years. The mean of HD duration was 71.36 months.