Evaluation of the Potential of Antiangiogenic and Antilymphangiogenic Compounds on Radio-sensitivity of Tumor Cells

Abstract

Cancer metastasis accounts for approximately 90% of all cancer related deaths. Robust neovascularization and lymphangiogenesis are found in a variety of aggressive malignant tumors and contribute to tumor progression and cancer metastasis (Gomes et al., 2013). Current dietary guidelines to combat chronic diseases including cancer, recommend increased intake of plant foods that are rich in antioxidants, including carotenoids, flavonoids and tanshinones (Mehmet et al., 2012). Apigenin (4, 5, 7 trihydroxyflavone) is a common dietary flavonoid. It has low toxicity, is non mutagenic and is widely distributed in the leaves and stems of dietary tropical vegetables and fruits such as bell pepper, snake gourd and wolfberry leaves Apigenin inhibited tumor angiogenesis which was associated with the decrease of VEGF expression in tumor tissues (Fang et al., 2007).