EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC POTENTIALS OF WHITE BEANS, ONION AND DATE SEEDS ON BLOOD SERUM OF RATS

Abstract

In the present study, the hypoglycemic, hypolipidemic, and hepatoprotective effect of white bean, date seeds extract and onion extract on alloxan induced diabetic rats was investigated. Forty five male albino rats were used in this experiment. Rats fed on white bean, date seeds extract and onion extract showed marked reduction of glucose, total cholesterol, triglycerides, LDL- cholesterol and VLDL- cholesterol when compared to positive control. The phytochemical analysis revealed the presence of flavonoids, tannins, glycosides, polyphenol and saponins in all used materials. Onion extract has the most important hypoglycemic and hypolipidemic effects on rat's serum. It's hypoglycemic and hypolipidemic effects could represent a protective mechanism against the development of hyperglycemia and hyperlipidemic characteristic of diabetes mellitus. Also liver function have been improved and there were significant reduction in aspartate aminotransferase (AST) and alanine aminotransferase (ALT), comparing with positive control group, as treatment of diabetes rats with white bean, date seeds extract and onion extract could restore the changes of their enzymes near to their normal levels.