New Combined Modality Treatment for Pediatric Hodgkin's Disease (p-NCI-HD 97)
Abir Mokhless Gadalla;
Abstract
Pediatric Hodgkin's disease is an outstanding example for a pediatric malignancy, which can now be cured in the vast majority of children, without a significant risk of adverse side-effects, mostly achieved by combination treatment (Potter, 1999).
One hundred twenty one patients with a histopathologic diagnosis of Hodgkin's disease presented to the Pediatric Oncology unit of the N.C.I., Cairo University, from June 1997 to June 1999, were studied and followed up. They were all previously untreated. Their age ranged from 3 to 18 years with a mean of 9.6±4 years and a median of 9 years. The male to female ratio was 2.8:1. Constitutional (B) symptoms were found in
76/121 patients (62.8%). Its presence was directly proportional to
stage of the disease.
Cervical nodal enlargement was by far the most common presentation. It was founin 82.6% of patients. Bulky disease was present in 56/121 patients (46.2%).
Mixed cellularity variant was the most common histopathologic subtype. It was present in 54.5% of patients, followed the nodular sclerosis subtype (23.1%), then the lymphocytic predominance subtype (15.7%), while only 2 patients had histopathologic features of lymphocytic rich subtype.
Out of the 121 patients, 56(46.2%) proved to have intrathoracic disease as evidence by pathologic CT chest.
One hundred twenty one patients with a histopathologic diagnosis of Hodgkin's disease presented to the Pediatric Oncology unit of the N.C.I., Cairo University, from June 1997 to June 1999, were studied and followed up. They were all previously untreated. Their age ranged from 3 to 18 years with a mean of 9.6±4 years and a median of 9 years. The male to female ratio was 2.8:1. Constitutional (B) symptoms were found in
76/121 patients (62.8%). Its presence was directly proportional to
stage of the disease.
Cervical nodal enlargement was by far the most common presentation. It was founin 82.6% of patients. Bulky disease was present in 56/121 patients (46.2%).
Mixed cellularity variant was the most common histopathologic subtype. It was present in 54.5% of patients, followed the nodular sclerosis subtype (23.1%), then the lymphocytic predominance subtype (15.7%), while only 2 patients had histopathologic features of lymphocytic rich subtype.
Out of the 121 patients, 56(46.2%) proved to have intrathoracic disease as evidence by pathologic CT chest.
Other data
| Title | New Combined Modality Treatment for Pediatric Hodgkin's Disease (p-NCI-HD 97) | Other Titles | نظام علاجى مزدوج جديد ( كيميائي وأشعاعي ) لعلاج سرطان الغدد الليمفاوية فى الأطفال مرض هودجكين | Authors | Abir Mokhless Gadalla | Issue Date | 2001 |
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