Plas1na E-selectin Level in Type II Diabetic Patients

Abstract

E-selectin is a member of the selectin family which compriss E, P

and L selectins. The selectin family is a family of the cell adh'

esion

molecules whish are cell surface proteins involved in cell binding ,usually I

to leukocytes, to each other, to endothelial cells or to extracellular ma&ix. E-selectin is expressed on activated endothelial cells in respohse to inflammation or tissue injury, where it functions cooperatively withjother selectins in mediating the rolling phase of leukocytes on endothelium\prior to its migration to site of injury. It is also involved in other physiol gical I functions including : homing of leukocytes to the skin, angiogenesiand support binding of hematopoietic progenitor cells to endothelial cells. I

E-selectin has the same. basic structure as other selectins: arhino I terminus with lectin like domain, short consensus repeat and epidermal growth factor like domains with short cytoplasmic tail. It is present inllow undetectable quantities on resting endothelial cells. Increased expresLon I occurs as a result of tissue injury, where it mediates the selectin binding I phase of leukocytes. I I

It is

Diabetes mellitus is a primary disorder of carbohydrate metabolAm. I mainly of two types : Type 1 or insulin dependent diabetes mell tus

and type 2 or non insulin dependent diabetes mellitus.