THE PREDICTIVE VALUE OF CARBOXYHEMOGLOBIN IN CRITICALLY ILL TRAUMATIZED PATIENTS.

Abstract

Endogenous CO is derived from conversion of heme to biliverdin under the effect of HO enzyme during catabolism of hemoglobin. CO concentration is increased under the effect of many stimuli as complement activation, oxidative stress, hyperthermia and certain cytokines as interleukin-1 and tumour necrosis factor alpha. Trauma and sepsis evoke a constellation of metabolic changes in the body. The magnitude of the response is proportional to the extent of llljury. Although our knowledge with CO is long standing, yet the role played by it as a mediator of metabolic response in critically ill patients is undergoing very extensive and active research. The above considerations have triggered us to study the issue of COH

level as a predictive value in correlation to SAPS II scoring system for measuring the severity of critical illness in traumatized patients. The present study comprised 20 polytraumatized patients admitted

to surgical I.C.U. in Mansoura Emergency Hospital with recent trauma less than 6 hours and revised trauma score less than 1 1.