STUDY OF SOME TUBULAR MARKERS IN DIABETIC NEPHROPATHY

Abstract

Diabetic neplopathy is one of the most common causes of end­ I stage renal diseasJ. It represents a significant risk for morbidity and I mortality among /both Je 1 and type 2 diabetic patients. The I development of early marJers to detect incipient diabetic nephropathy I

and

to mom•tor evIentua1 prIogressw• n from si•1ent towards overt dI'sease I•S I

therefore importadt. The datural history of diabetic nephropathy is well I known the . appeJance of kicroalbuminuria is later followed by dipstick I positive proteinuril and the development of renal failure. These processes I are believed to rlflect glomerular changes, However it is proposed that I the tubulomterstitia l.clhang"els p1ay an I. mportant role m t e progressi.on of I renal failure. ThJ presen+ of a clinical marker of this morphological I damage may be lore sensitive in detecting early and reversible stages of I the disease. Tub{lar protfinuria and enzymuria have been proposed as I useful markers oftubular damage. I I The aim of the present work is to study some tubular markers in I <liabotio noplrrop rY• • c> I I The study was cIonductedI on 4 groups of diabetic patients and 10 nor. mal I subjects as a control grou)Y. a£ I GroupI: Include&10 type 1 diab tic patients with microalbuminuria. I Group2: Includek 10 type 1 diabetic patients with proteinuria. I Group3: Includeld 10 typJ + diabetic patients with microalbuminuria. I Group4: Included 10 typd 2 diabetic patients with proteinuria. I