Preparation of Porous Zirconium Molybdate and Titanium Molybdate as Gel Materials for99Mo/99mTc Chromatographic Column Generators
Mostafa Atef Abdel-Satar Abdel-Aal;
Abstract
The main purpose of this dissertation is to prepare porous nano zirconium molybdate gel and nano titanium molybdate gel (as beds for 99Mo/99mTc column generators) with new method using pore-forming and stabilizing agents to enhance the elution yield and improve the specification of the eluted technetium-99m.
Porous nano zirconium molybdate and porous nano titanium molybdate gel materials were precipitated in the presence of 99Mo radiotracers (Zr99Mo and Ti99Mo gels) from aqueous solutions at different preparation conditions. In general, the use of nano-sized particles and highly porous materials as base materials for 99Mo/99mTc column generators may lead to elution of 99mTc with high yields due to the large surface area (as a result of small particle size) and the ease of diffusion of saline solution eluent (0.9 % NaCl) through the porous structure.
The optimum Zr99Mo gel was precipitated (quantitative precipitation of 99Mo was achieved) from chloride aqueous solution at pH 5 in the presence of 3 g urea with Zr:Mo molar ratio of 1.3:1 and dried at 100 °C. The optimum ZrMo gel is a white colored material in the form of fine granules with total pore volume of 2.2 × 10-2 cm3/ g, pore size of ≤ 1044 Å, average crystallite size of 22.0 nm and average particle size of 49.2 nm. Technetium-99m was eluted from the 99Mo/99mTc column based on the optimum Zr99Mo with elution yield of 86 ± 2 %, 99Mo breakthrough of 1 × 10-3 %, pH of 6-6.5, radiochemical purity of 97.5 % (as 99mTcO4-) and high chemical purity (only ≤ 1 ppm Mo and ≤ 0.3 ppm Zr were found in the 99mTc eluates).
The optimum Ti99Mo was precipitated (99Mo precipitation yield was 99.9 %) from NH3 aqueous solution at pH 5 in the presence of 0.02 M Ce(IV) with Ti:Mo molar ratio of 1.3:1 and dried at 50 °C. The optimum TiMo gel is a yellowish brown colored material in the form of fine granules with total pore volume of 4.1 × 10-2 cm3/cm, pore size of ≥ 687 Å, average crystallite size of 36.1 nm and average particle size of 58.1 nm. Technetium-99m was eluted from the 99Mo/99mTc column based on the optimum Ti99Mo gel with elution yield of 88 ± 1 %, 99Mo breakthrough of 5 × 10-3 %, pH of 6-6.5, radiochemical purity of 98.2 % (as 99mTcO4-) and high chemical purity (only ≤ 1 ppm Mo, ≤ 0.5 ppm Ti and ≤ 0.2 ppm Ce were found in the 99mTc eluates).
Keywords: [Nano Zr99Mo,Nano Ti99Mo,99Mo/99mTc column, performance,99mTc elution, hydrothermal process]
Porous nano zirconium molybdate and porous nano titanium molybdate gel materials were precipitated in the presence of 99Mo radiotracers (Zr99Mo and Ti99Mo gels) from aqueous solutions at different preparation conditions. In general, the use of nano-sized particles and highly porous materials as base materials for 99Mo/99mTc column generators may lead to elution of 99mTc with high yields due to the large surface area (as a result of small particle size) and the ease of diffusion of saline solution eluent (0.9 % NaCl) through the porous structure.
The optimum Zr99Mo gel was precipitated (quantitative precipitation of 99Mo was achieved) from chloride aqueous solution at pH 5 in the presence of 3 g urea with Zr:Mo molar ratio of 1.3:1 and dried at 100 °C. The optimum ZrMo gel is a white colored material in the form of fine granules with total pore volume of 2.2 × 10-2 cm3/ g, pore size of ≤ 1044 Å, average crystallite size of 22.0 nm and average particle size of 49.2 nm. Technetium-99m was eluted from the 99Mo/99mTc column based on the optimum Zr99Mo with elution yield of 86 ± 2 %, 99Mo breakthrough of 1 × 10-3 %, pH of 6-6.5, radiochemical purity of 97.5 % (as 99mTcO4-) and high chemical purity (only ≤ 1 ppm Mo and ≤ 0.3 ppm Zr were found in the 99mTc eluates).
The optimum Ti99Mo was precipitated (99Mo precipitation yield was 99.9 %) from NH3 aqueous solution at pH 5 in the presence of 0.02 M Ce(IV) with Ti:Mo molar ratio of 1.3:1 and dried at 50 °C. The optimum TiMo gel is a yellowish brown colored material in the form of fine granules with total pore volume of 4.1 × 10-2 cm3/cm, pore size of ≥ 687 Å, average crystallite size of 36.1 nm and average particle size of 58.1 nm. Technetium-99m was eluted from the 99Mo/99mTc column based on the optimum Ti99Mo gel with elution yield of 88 ± 1 %, 99Mo breakthrough of 5 × 10-3 %, pH of 6-6.5, radiochemical purity of 98.2 % (as 99mTcO4-) and high chemical purity (only ≤ 1 ppm Mo, ≤ 0.5 ppm Ti and ≤ 0.2 ppm Ce were found in the 99mTc eluates).
Keywords: [Nano Zr99Mo,Nano Ti99Mo,99Mo/99mTc column, performance,99mTc elution, hydrothermal process]
Other data
| Title | Preparation of Porous Zirconium Molybdate and Titanium Molybdate as Gel Materials for99Mo/99mTc Chromatographic Column Generators | Other Titles | تحضيــر موليبدات الزركونيـــوم ومـــوليبدات التيتانيــــوم المســـاميتين كمادتين هلاميتيـن للأعمدة الكروماتوجرافيـة لمولـــــــــدات الموليبدنيـــــــوم-99 / التكنيسيـــــــوم-99م | Authors | Mostafa Atef Abdel-Satar Abdel-Aal | Issue Date | 2017 |
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