Study on placental prostate-specific antigen in preeclamptic Egyptian women

Abstract

The present study was undertaken to elucidate the mechanisms for the pathogenesis of preeclampsia (PE) in Egyptian women. To fulfill the target of the study, a total of fifty women at delivery were recruited, including twenty five pregnant women with preeclampsia and twenty five normotensive pregnant females. The biomarkers studied included blood pressure, complete blood picture, albuminuria as well as placental prostate specific antigen (PSA), 17-β estradiol (E2), interleukin-6 (IL-6), lipid peroxidation (MDA), glutathione peroxidase (GPx) and trace elements (Zinc, Copper and Calcium). Our results demonstrated a significant difference in the systolic blood pressure (p<0.001), diastolic blood pressure (p<0.001), albuminuria (p<0.001), platelets (p<0.049), hemoglobin (p<0.014), placental PSA (p<0.002), IL-6 (p< 0.05) and 17-β estradiol (p<0.012) in preeclamptic women compared with normotensive pregnant women. In addition, a positive correlation was recorded between placental PSA and each of systolic blood pressure, diastolic blood pressure, platelets and albuminuria whereas a negative correlation was recorded between placental PSA and each of placental IL-6 and 17-β estradiol.