Correlation Of Serum Vitamin D Level with Coronary Artery Disease Severity

Abstract

Vitamin D is a group of fat-soluble prohormones, the two major biologically inert precursors of vitamin D are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). Low serum vitamin D level may associated with musculoskeletal diseases, Immune diseases as Rheumatoid Arthritis, Cancer, Diabetes mellitus, metabolic syndrome, and Neuropsychiatric diseases. Previous studies suggest conjunctions between vitamin D and cardiovascular diseases as hypertension, peripheral vascular diseases, myocardial disease and heart failure. In our study, we tried to demonstrate the correlation between serum vitamin D level and CAD in patients underwent coronary angiography and assessed the severity of CAD by the Gensini score. Among the study, we found a strong significant negative correlation between vitamin D level and the severity of CAD. These results were matching those of previous studies that found significant correlation between vitamin D level and CAD. Other negative significant correlations were found in our study between vitamin D levels and each of RWMSI, BMI, LVH, and hyperlipidemia, the only positive correlation of vitamin D was with left ventricular end systolic dimension. We also found correlations between Gensini score and echocardiographic parameters as Gensini score was positively correlated with RWMSI and negatively correlated with left ventricular end systolic dimension. This emphasizes the role of echocardiogram as a prognostic factor for the severity of CAD.