Magnetic Resonance spectroscopy in patients with Thalassemia Major

Abstract

In our study, there was a significant positive correlation between NAA/Cr and Wechsler Intelligence Scale for Children, and patients with reduced NAA /Cr ratio had a significantly higher abnormal scores on Benton Visual Retention Test (BVRT) with a significant negative correlation between NAA/Cr and BVRT. Also, Wisconsin Card Sort Test scores were significantly lower in patients with reduced NAA/Cr ratio and WCST showed a significant positive correlation with NAA/Cr ratio Additionally reduced NAA/Cr ratio is a marker of cortical neuronal loss and dysfunction in schizophrenia. In 2009 Pedersen et al they correlated the level NAA/Cr with performance on the dynamic WCST in patients with schizopherenia as well as healthy subjects. And a significant correlation was observed between NAA/Cr and learning potential on WCST. ALSO Galińska et al.( 2007) found that Cognitive impairment related to dysfunction of the prefrontal cortex in first-episode schizophrenia is associated with reduction of NAA /Cr in the frontal lobe. AND NAA/Cr in the frontal lobe were significantly related to poorer WCST performance. Also, Reduced NAA/Cr ratio is a marker of cortical neuronal loss and dysfunction in amyotrophic lateral sclerosis (ALS). Moreover, NAA levels in the motor area and frontal lobe correlate with the clinical features ALS, including frontal lobe function (Abe et al., 2001). As per their study in 2001, Abe et al. found that the NAA/Cr ratio was reduced in the motor area and frontal lobe of the brain of 14 patients with clinically definite (ALS) compared to controls with a significant correlations between the NAA/Cr ratio and the number of categories achieved in the Wisconsin Card Sorting test, implying frontal lobe dysfunction.