Immunohistochemical Expression of Stem Cell Marker Musashi 1(Msi-1) in Colorectal Carcinoma and Its Correlation With various pathologic Parameters

Abstract

Colorectal cancer is the third most common cancer in men and the second in women (Ferlay et al., 2015). There are significant international variations in the distribution of colorectal cancer (center et al. 2009 ; Parkin et al.,2011) with 60% of CRC occurring in developed regions and countries that have experienced a rise in prosperity, such as Japan. The highest rates of CRC are in Western Europe and Australia/New Zealand, and the lowest rates are in Africa (excluding Southern Africa) and South-Central Asia (Ferlay et al., 2015). In Egypt, The Cancer Pathology Registry of National Cancer Institute, Cairo University showed that during the years 2003-2004, colorectal cancer occupied the first rank among digestive system malignancies (15.78%) and the fifth among all cancers (4.34%) (Mokhtar et al., 2007). And according to the Pathology Based Cancer Registry 2001-2010, Faculty Of Medicine, Ain Shams University, colorectal cancer represents the first rank of digestive system malignancies ( 42.6%) and ( 8.8) % of total malignancies (Helal et al.,2015) Many Factors such as tumor size, histological type, presence of signet ring morphology as well as lymph node involvement are well known factors that influence the outcome in CRC (Ola Marzouk and John Schofield, 2011).