Impact of Helicobacter pylori Infection on Liver Histopathology in Egyptian Patients with Chronic Hepatitis C infection

Abstract

SUMMARY UMMARYUMMARYUMMARYUMMARY irrhosis is a chronic (ongoing, long-term) disease of the liver. It means damage to the normal liver tissue that prevents this important organ from working as it should. If the damage is not stopped, the liver gradually loses its ability to carry out its normal functions. This is called liver failure, sometimes referred to as end-stage liver disease. Cirrhosis of the liver is disease found all over the world, affecting all races, age groups and both sexes. The clinical presentation of liver cirrhosis is often asymptomatic until complications appear. Hepatitis C virus (HCV) is considered the most common etiology of chronic liver disease in Egypt, which may progress to cirrhosis and hepatocellular carcinoma (HCC). Previous studies have documented an association between Helicobacter pylori (H. pylori) infection and liver cirrhosis with or without HCC. This study aimed to investigate the presence of H. pylori in the liver tissue of Egyptian patients with chronic hepatitis C (CHC). One-third of patients with liver cirrhosis suffers from acute peptic ulcer, a disease strongly correlated with C Summary  101 Helicobacter pylori infection. There is an association between the presence of H.pylori with chronic active hepatitis and peptic ulcer.