Preparation and In-vivo Biological Evaluation of Some Organic Compounds as Radionuclide Carriers for Medical Application

Abstract

Technetium is the most widely used radionuclide in diagnostic nuclear medicine due to its nearly ideal physical and nuclear properties as well as its availability. Selection of 99mTc-dioxime derivatives to target tumor is based on the reported finding that dioxime derivatives capable of complexing with reduced Tc-99m allowing us to image tumor sites using a gamma camera. In this study, both diamino pyrimidine and diamino cyclohexane were selected as a precursor for synthesis of dioxime derivatives. This thesis comprises three parts in addition to references. 1. Introduction comprises the introduction which presents brief accounts on radiochemistry, radioactivity, radioisotopes and nuclear medicine, technetium-99m, radiopharmaceuticals, labeling with 99mTc, labeling methods with 99mTc and technetium generations. This introduction also includes brief accounts on oxime, anticancer effect of dioxime, dioximes applications and