Signal joint T-cell Receptor Rearrangement Excision Circle as a Potential Marker for Age Estimation in a Sample of Egyptians

Abstract

Abstract Age can be determined very accurately in childhood using developmental methods like dental eruption, dimensions of bones, presence of ossification centers and epiphyseal fusion. However, in adults this methodology is less accurate. For that reason, new biochemical and molecular methodologies have been developed. Biochemical methods are based on the natural process of aging, which including different biochemical changes that lead to age related alterations in cells and tissues. Some methods that could be used in age estimation, such as aspartic acid racemization, collagen content in human teeth, bone and cartilage and lead accumulation in teeth. Molecular biology approaches analyzed DNA alterations that occur with aging such as age-dependent accumulation of deletions that occur in mitochondrial DNA, telomere shortening and DNA methylation.