Long -Term Kidney Outcomes among Users of Proton Pump Inhibitors
Nehal Magdy Messiha Abdelmalak;
Abstract
SUMMARY
T
o summarize, PPIs represent an essential part of the modern gastroenterologist’s armament for combating everyday clinical problems. In general, they are highly efficacious in the treatment of acid-related disorders.
While PPIs are generally considered safe and well tolerated, more serious adverse events have been reported. The risk of pneumonia was increased 27–39% in short-term use of PPIs in three meta-analyses. The use of PPIs is associated with Clostridium difficile infection and appears to be dose related. Fractures and the impaired magnesium absorption associated with the use of PPIs have led the FDA to issue a warning regarding their use. Thrombocytopenia, iron deficiency, vitamin B12 deficiency, rhabdomyolysis and acute interstitial nephritis have also been reported with the use of PPIs.
Some recent studies has suggested that Proton pump inhibitor use is linked with a higher risk of chronic kidney disease (CKD) being held on a large number of patients with different co-morbidities and chronic diseases for a long period of time.
T
o summarize, PPIs represent an essential part of the modern gastroenterologist’s armament for combating everyday clinical problems. In general, they are highly efficacious in the treatment of acid-related disorders.
While PPIs are generally considered safe and well tolerated, more serious adverse events have been reported. The risk of pneumonia was increased 27–39% in short-term use of PPIs in three meta-analyses. The use of PPIs is associated with Clostridium difficile infection and appears to be dose related. Fractures and the impaired magnesium absorption associated with the use of PPIs have led the FDA to issue a warning regarding their use. Thrombocytopenia, iron deficiency, vitamin B12 deficiency, rhabdomyolysis and acute interstitial nephritis have also been reported with the use of PPIs.
Some recent studies has suggested that Proton pump inhibitor use is linked with a higher risk of chronic kidney disease (CKD) being held on a large number of patients with different co-morbidities and chronic diseases for a long period of time.
Other data
| Title | Long -Term Kidney Outcomes among Users of Proton Pump Inhibitors | Other Titles | مثبطات مضخة البروتون ونتائج استخدامها طويل المدى على الكلى | Authors | Nehal Magdy Messiha Abdelmalak | Issue Date | 2017 |
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