Adjusted Serum leptin and leptin Adiponectin ratio in correlation with Hyperemesis gravidarum

Abstract

Hyperemesis gravidarum [HG] is a significant but underappreciated illness of pregnancy. It is the most common indication for admission to the hospital in the first half of pregnancy and second only to preterm labour as a cause of hospitalization overall. Hyperemesis gravidarum is a state characterized by intractable vomiting during pregnancy, leading to dehydration, ketonemia, electrolyte imbalance and weight loss . Nausea and vomiting is a common symptom of early pregnancy. Affecting up to 80 % of women. While the reported incidence of hyperemesis gravidraum is 0. 5-2. 0%. Although recent research say that the pathophysiology for hyperemesis gravidraum is not clear. It has been proposed that hormonal allergen, genetic factors, immunolgical, neuropsychosomotic, metabolic factors may play a role in the etiology of hyperemsis gravidraum . Leptin and adiponectin are the hormones that are secreated mainly by the adipose tissue to signal the status of body energy stores to the central nervous system. As a signal of energy sufficiency, adequate leptin levels suppress feeding and permit energy-costly neuro endocrine functions. Leptin is a circulating hormone which acts as an afferent satiety signal to regulate body weight and